Tyler Johnson, PhD

Dr. Johnson joined the Department of Natural Sciences and Mathematics in 2014. He received a B.A. in Molecular Cellular and Development Biology and a PhD in Chemical Oceanography from UC Santa Cruz. He conducted postdoctoral studies at UC Berkeley in collaboration with UC Davis, UC Santa Cruz and UCSF. His background is in the area of analytical and bioorganic chemistry with an emphasis in biomedical research involving natural products. The goal of the Johnson laboratory is to chemically validate biologically active terrestrial and marine-derived natural products to serve as: a) therapeutic lead molecular structures for treating cancer, inflammation and neurobiological disorders or b) novel molecular probes in chemical biology research. Dr. Johnson has taught general chemistry 2000 and 2100, Biology and Chemistry Research Methodology and Science Seminar Bio 3501.

Tyler A. Johnson, PhD

Tyler Johnson

Assistant Professor
Office: Science Center #128
Lab: Science Center #110
415-482-1983
tyler.johnson@dominican.edu

 

Academic Area

Analytical, Bioorganic and Natural Products Chemistry, Chemical Biology.

Educational Background

  • PhD, Chemical Oceanography - Marine Natural Products Chemistry, UC Santa Cruz. Santa Cruz, CA.
  • BA, Molecular, Cellular and Developmental Biology, UC Santa Cruz. Santa Cruz, CA.

Publications

Johnson, T. A.; Milan-Lobo, L.; Che, T.; Ferwerda, M.; Lambu, E.; McIntosh, N. L.; Li, F.; He, L.; Lorig-Roach, N.; Crews, P. Whistler, J. L. Identification of the First Marine-Derived Opioid Receptor “Balanced” Agonist with a Signaling Profile That Resembles the Endorphins ACS Chemical Neuroscience, 2016, in press.

Theodore, C. M.; Lorig-Roach, N.; Still, P.; Johnson, T. A.; Drašković, M.; Naphen, C.; Crews, M. S.; Valeriote, F. A. Lokey, R. S., Crews, P. Biosynthetic Products from a Near shore-derived Gram-Negative Bacterium Enable Reassessment of the Kailuin Depsipeptides. Journal of Natural Products, 2015, 8, 441–452. PMID: 25699470

Still, P. C.; Johnson, T. A.; Theodore, C. M.; Loveridge, S. L. and Crews. P. Scrutinizing the Scaffolds of Marine Biosynthetics from Different Source Organisms: Gram-Negative Cultured Bacterial Products Enter Center Stage. Journal of Natural Products, 2014, 15, 690-702. ACS editors choice award. PMID: 24571234

Johnson, T.A.; Sohn, J.; Ward, A.E.; Cohen, T.L.; Lorig-Roach, N. D.; Pilli, R.A..; Kardono, L. B. S.; Lotulung, P.D.; Boundy-Mills, K.; Bjeldanes, L.F. (+)-Altholactone Exhibits Broad Spectrum Immune Modulating Activity by Inhibiting the Activation of Pro-inflammatory Cytokines in RAW 264.7 Cell Lines. Bioorganic and Medicinal Chemistry, 2013, 21, 4358-4364. PMID: 23735825

Rohena, C. C.; Johnson, T. A.; Crews, P., Mooberry, S. L. Chemically Diverse Microtubule Stabilizing Agents Initiate Distinct Mitotic Signaling Defects. Biochemical Pharmacology, 2013, 85, 1104-1114. PMID: 23399639

Johnson, T. A.; Sohn, J.; Inman, W. D.; Bjeldanes, L. F.; Rayburn, K. Lipophilic Stinging Nettle Extracts Possess Potent Anti-inflammatory Activity, Are Not Cytotoxic and May Be Superior to Traditional Tinctures for Treating Inflammatory Disorders. Phytomedicine, 2013, 20, 143-147. PMID: 23092723

Valeriote, F. A.; Tenney, K.; Media, J.; Pietraszkewicz, H.; Edelstein, M.; Johnson, T. A.; Amagato, T.; Crews, P. Discovery and Development of Anticancer Agents from Sponges: Perspectives Based on a Chemistry-experimental Therapeutics Collaborative Program. Journal of Experimental Therapeutics and Oncology, 2012, 10, 119-134. PMID: 23350352

Schwartz, K. H.; Valeriote, F. A.; Media, J.; Johnson, T. A.; Tenney, K.; Crews, P.; Shaw, J. Development and Validation of Simple Method for the Detection of Fascaplysin in Plasma. Journal of Analytical and Bioanalytical Techniques, 2012, 3, 150. doi: 10.4172/2155-9872.1000150.

Johnson, T. A.; Sohn, J; Vaske, Y. M.; White, K. N.; Cohen, T. L.; Vervoort, H. C.; Tenney, K.; Valeriote, F. A.; Bjeldanes, L. F.; Crews, P. Myxobacteria vs. Sponge-Derived Alkaloids: The Bengamides Identified as Potent Immune Modulating Agents by Scrutiny of LCMS/ELSD Libraries. Bioorganic and Medicinal Chemistry, 2012, 15, 6900-6908. PMID: 22705020

Johnson, T. A.; Sohn, J.; Inman, W. D.; Estee, S. A.; Loveridge, S. T.; Vervoort, H. C.; Tenney, K.; Ang, K. K.; Ratnam, J.; Bray, W. M.; Gassner, N. C.; Shen, Y. Y.; Lokey, R. S.; McKerrow, J. H.; Boundy-Mills, K.; Nukanto, A.; Kanti, A.; Julistiono, H.; Kardono, L.; Bjeldanes, L. F.; Crews, P. Natural Product Libraries to Accelerate the High Throughput Discovery of Therapeutic Leads. Journal of Natural Products, 2011, 74 12, 2545–2555. PMID: 20030364

Wu, Q; Crews, M.; Draskovic, M.; Sohn, J.; Johnson, T. A.; Tenney, K.; Valeriote, F.A.; Yao, X.; Bjeldanes, L.F.; Crews, P. Azonazine, A Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus ochraceopetaliformis. Organic letters, 2010, 12, 4458-4461. PMID: 20866076

Morgan, B.J.; Mahdi, F.; Liu, Y.; Coothankandaswamy, V.; Jekabsons, M. B.; Johnson, T. A.; Sashidhara, K.V.; Crews, P.; Nagle, D. G.; Zhou, Y. The Marine Sponge Metabolite Mycothiazole: A Novel Prototype Mitochondria Complex I Inhibitor. Bioorganic and Medicinal Chemistry, 2010, 18, 5988-5994. PMID: 20637638

Johnson, T. A.; Morgan, M.; Aratow, N.; Estee, S. A.; Sashidhara, K. V.; Loveridge, S.; Segraves, N.L.; Crews, P. Assessing Pressurized Solvent Extraction for the High Throughput Extraction of Marine-Sponge Derived Natural Products. Journal of Natural Products, 2010, 73, 359–364. Special issue honoring Prof. J. Daly & R. Moore. PMID: 20030364

Shaw, J.; Valeriote, F. A.; Meida, J.; Johnson, T. A.; Amagata, T.; Tenney, K. and Crews, P. Development and Validation of a Rapid Method for the Detection of Latrunculol A in Plasma. Analytical & Bioanalytical Chemistry, 2010, 396, 1741-1744. PMID: 20043220

Johnson, T. A.; Amagata, T.; Sashidhara, K. V.; Oliver, A. G.; Tenney, K.; Matainaho, T.; Kean-Hooi Ang, K.; McKerrow, J. H; Crews, P. The Aignopsanes, a New Sesquiterpene Class, from Selected Chemotypes of the Sponge Cacospongia mycofijiensis. Organic letters, 2009, 11, 1975-1978. PMID: 19385671

Jessup, D.A.; Miller, M.A.; Ryan, J.P.; Nevins, H. M.; Kerkering, H. A.; Mekebri, A.; Crane, D. B.; Johnson, T. A.; Kudela, R. M. Mass Stranding of Marine Birds Caused by a Surfactant-Producing Red Tide. PLoS One 2009, 4 (2): e4550. PMID: 19234604

Johnson, T. A.; Amagata, T.; Oliver, A. G.; Tenney, K.; Valeriote, F. A.; Crews, P. The Unexpected Isolation of CTP-431, a Novel Cytotoxic Thiopyrone from the Sponge Cacospongia mycofijiensis. Journal of Organic Chemistry, 2008 73, 7255-7259. PMID: 18715038

Amagata, T; Johnson, T.A.; Cichewicz, R. H.; Tenney, K.; Mooberry, S. L.; Valeriote, F. A.; Crews, P. Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonimcally Unrelated Sponges. Journal of Medicinal Chemistry, 2008, 51, 7234-7242. PMID: 18942825

Litaker, R. W.; LeEberhardt, B.; Wekell, J. C.; Trainer, V. L.; Kudela, R. M.; Roberts, A.; Hertz, C.; Johnson, T. A.; Frankfurter, G.; Smith, J. G.; Schnetzer, A.; Stewart, T.; Hardison, R.; Tester, P. Rapid Enzyme-liked Immunosorbent Assay for Detection of the Algal Toxin Domoic Acid. Journal of Shellfish Research, 2008, 27, 1301-1310.

Johnson, T. A.; Tenney, K.; Cichewicz, R. H.; Morinaka, B. I.; White, K. N.; Amagata, T.; Subramanian, B.; Media, J.; Mooberry, S. L.; Valeriote, F. A.; Crews, P. Sponge-Derived Fijianolide Polyketide Class: Further Evaluation of Their Structural and Cytoxicity Properties. Journal of Medicinal Chemistry, 2007, 50, 3795-3803. PMID: 17622130

Deschamps, J. D.; Gautschi, J. T.; Whitman, S.; Johnson, T. A.; Gassner, N. C.; Crews, P.; Holman, T. H. Discovery of Platelet-type 12-Human Lipoxygenase Selective Inhibitors by High-throughput Screening of Structurally Diverse Libraries. Bioorganic & Medicinal Chemistry, 2007, 15, 6900-6908. PMID: 17826100.

Sonnenschein, R. N.; Johnson, T. A.; Tenney, K.; Valeriote, F.; Crews, P. A Reassignment of (-)-Mycothiazole and the Isolation of a Related Diol. Journal of Natural Products, 2006, 6, 145- 147. PMID: 16441088

Segraves, E. N.; Shah, R. R.; Segraves, N. L.; Johnson, T. A.; Whitman, S.; Sui, J. K.; Kenyon, V. A.; Cichewicz, R. H.; Crews, P.; Holman, T. Probing the Activity of Simple and Complex Brominated Aryl Compounds against 15-Soybean, 15-Human, and 12-Human Lipoxygenase. Journal of Medicinal Chemistry, 2004, 47, 4060-4065. PMID: 15267244

Amagata, T.; Whitman, S.; Johnson, T. A.; Stessman, C. C.; Loo, C. P.; Lobkovsky, E.; Clardy, J.; Crews, P.; Holman, T.; Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity against 12-Human, 15-Human, and 15-Soybean Lipoxygenases. Journal of Natural Products, 2003, 66, 230-235. PMID: 12608855

Seagraves, N. L.; Lopez, S.; Johnson, T. A.; Said, S. A.; Fu, X.; Schmitz, F. J.; Pietraszkiewicz, H.; Valeriote, F. A.; Crews, P. Structures and Cytotoxicities of Fascaplysin and Related Alkaloids from Two Marine Phyla__Fascaplysinopsis Sponges and Didemnum Tunicates. Tetrahedron Letters, 2003, 44, 3471-3475.

Thale, Z.; Johnson, T. A.; Tenney, K.; Wenzel, P. J.; Lobkvovsky, E.; Clardy, J.; Media, J.; Pietraszkiewicz, H.; Valeriote, F. A.; Crews, P. Structures and Cytotoxic Properties of Sponge-Derived Bisannulated Acridines. Journal of Organic Chemistry, 2002, 67, 9384-9391. PMID: 12492342

Theodore, C. M.; Lorig-Roach, N.; Still, P.; Johnson, T. A.; Drašković, M.; Naphen, C.; Crews, M. S.; Valeriote, F. A. Lokey, R. S., Crews, P. Biosynthetic Products from a Nearshore-derived Gram-Negative Bacterium Enable Reassessment of the Kailuin Depsipeptides. Journal of Natural Products, 2015, 8, 441–452. PMID: 25699470

Still, P. C.; Johnson, T. A.; Theodore, C. M.; Loveridge, S. L. and Crews. P. Scrutinizing the Scaffolds of Marine Biosynthetics from Different Source Organisms: Gram-Negative Cultured Bacterial Products Enter Center Stage. Journal of Natural Products, 2014, 15, 690-702. ACS editors choice award. PMID: 24571234

Johnson, T.A.; Sohn, J.; Ward, A.E.; Cohen, T.L.; Lorig-Roach, N. D.; Pilli, R.A..; Kardono, L. B. S.; Lotulung, P.D.; Boundy-Mills, K.; Bjeldanes, L.F. (+)-Altholactone Exhibits Broad Spectrum Immune Modulating Activity by Inhibiting the Activation of Pro-inflammatory Cytokines in RAW 264.7 Cell Lines. Bioorganic and Medicinal Chemistry, 2013, 21, 4358-4364. PMID: 23735825

Rohena, C. C.; Johnson, T. A.; Crews, P., Mooberry, S. L. Chemically Diverse Microtubule Stabilizing Agents Initiate Distinct Mitotic Signaling Defects. Biochemical Pharmacology, 2013, 85, 1104-1114. PMID: 23399639

Johnson, T. A.; Sohn, J.; Inman, W. D.; Bjeldanes, L. F.; Rayburn, K. Lipophilic Stinging Nettle Extracts Possess Potent Anti-inflammatory Activity, Are Not Cytotoxic and May Be Superior to Traditional Tinctures for Treating Inflammatory Disorders. Phytomedicine, 2013, 20, 143-147. PMID: 23092723

Valeriote, F. A.; Tenney, K.; Media, J.; Pietraszkewicz, H.; Edelstein, M.; Johnson, T. A.; Amagato, T.; Crews, P. Discovery and Development of Anticancer Agents from Sponges: Perspectives Based on a Chemistry-experimental Therapeutics Collaborative Program. Journal of Experimental Therapeutics and Oncology, 2012, 10, 119-134. PMID: 23350352

Schwartz, K. H.; Valeriote, F. A.; Media, J.; Johnson, T. A.; Tenney, K.; Crews, P.; Shaw, J. Development and Validation of Simple Method for the Detection of Fascaplysin in Plasma. Journal of Analytical and Bioanalytical Techniques, 2012, 3, 150. doi: 10.4172/2155-9872.1000150.

Johnson, T. A.; Sohn, J; Vaske, Y. M.; White, K. N.; Cohen, T. L.; Vervoort, H. C.; Tenney, K.; Valeriote, F. A.; Bjeldanes, L. F.; Crews, P. Myxobacteria vs. Sponge-Derived Alkaloids: The Bengamides Identified as Potent Immune Modulating Agents by Scrutiny of LCMS/ELSD Libraries. Bioorganic and Medicinal Chemistry, 2012, 15, 6900-6908. PMID: 22705020

Johnson, T. A.; Sohn, J.; Inman, W. D.; Estee, S. A.; Loveridge, S. T.; Vervoort, H. C.; Tenney, K.; Ang, K. K.; Ratnam, J.; Bray, W. M.; Gassner, N. C.; Shen, Y. Y.; Lokey, R. S.; McKerrow, J. H.; Boundy-Mills, K.; Nukanto, A.; Kanti, A.; Julistiono, H.; Kardono, L.; Bjeldanes, L. F.; Crews, P. Natural Product Libraries to Accelerate the High Throughput Discovery of Therapeutic Leads. Journal of Natural Products, 2011, 74 12, 2545–2555. PMID: 20030364

Wu, Q; Crews, M.; Draskovic, M.; Sohn, J.; Johnson, T. A.; Tenney, K.; Valeriote, F.A.; Yao, X.; Bjeldanes, L.F.; Crews, P. Azonazine, A Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus ochraceopetaliformis. Organic letters, 2010, 12, 4458-4461. PMID: 20866076

Morgan, B.J.; Mahdi, F.; Liu, Y.; Coothankandaswamy, V.; Jekabsons, M. B.; Johnson, T. A.; Sashidhara, K.V.; Crews, P.; Nagle, D. G.; Zhou, Y. The Marine Sponge Metabolite Mycothiazole: A Novel Prototype Mitochondria Complex I Inhibitor. Bioorganic and Medicinal Chemistry, 2010, 18, 5988-5994. PMID: 20637638

Johnson, T. A.; Morgan, M.; Aratow, N.; Estee, S. A.; Sashidhara, K. V.; Loveridge, S.; Segraves, N.L.; Crews, P. Assessing Pressurized Solvent Extraction for the High Throughput Extraction of Marine-Sponge Derived Natural Products. Journal of Natural Products, 2010, 73, 359–364. Special issue honoring Prof. J. Daly & R. Moore. PMID: 20030364

Shaw, J.; Valeriote, F. A.; Meida, J.; Johnson, T. A.; Amagata, T.; Tenney, K. and Crews, P. Development and Validation of a Rapid Method for the Detection of Latrunculol A in Plasma. Analytical & Bioanalytical Chemistry, 2010, 396, 1741-1744. PMID: 20043220

Johnson, T. A.; Amagata, T.; Sashidhara, K. V.; Oliver, A. G.; Tenney, K.; Matainaho, T.; Kean-Hooi Ang, K.; McKerrow, J. H; Crews, P. The Aignopsanes, a New Sesquiterpene Class, from Selected Chemotypes of the Sponge Cacospongia mycofijiensis. Organic letters, 2009, 11, 1975-1978. PMID: 19385671

Jessup, D.A.; Miller, M.A.; Ryan, J.P.; Nevins, H. M.; Kerkering, H. A.; Mekebri, A.; Crane, D. B.; Johnson, T. A.; Kudela, R. M. Mass Stranding of Marine Birds Caused by a Surfactant-Producing Red Tide. PLoS One 2009, 4 (2): e4550. PMID: 19234604

Johnson, T. A.; Amagata, T.; Oliver, A. G.; Tenney, K.; Valeriote, F. A.; Crews, P. The Unexpected Isolation of CTP-431, a Novel Cytotoxic Thiopyrone from the Sponge Cacospongia mycofijiensis. Journal of Organic Chemistry, 2008 73, 7255-7259. PMID: 18715038

Amagata, T; Johnson, T.A.; Cichewicz, R. H.; Tenney, K.; Mooberry, S. L.; Valeriote, F. A.; Crews, P. Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonimcally Unrelated Sponges. Journal of Medicinal Chemistry, 2008, 51, 7234-7242. PMID: 18942825

Litaker, R. W.; LeEberhardt, B.; Wekell, J. C.; Trainer, V. L.; Kudela, R. M.; Roberts, A.; Hertz, C.; Johnson, T. A.; Frankfurter, G.; Smith, J. G.; Schnetzer, A.; Stewart, T.; Hardison, R.; Tester, P. Rapid Enzyme-liked Immunosorbent Assay for Detection of the Algal Toxin Domoic Acid. Journal of Shellfish Research, 2008, 27, 1301-1310.

Johnson, T. A.; Tenney, K.; Cichewicz, R. H.; Morinaka, B. I.; White, K. N.; Amagata, T.; Subramanian, B.; Media, J.; Mooberry, S. L.; Valeriote, F. A.; Crews, P. Sponge-Derived Fijianolide Polyketide Class: Further Evaluation of Their Structural and Cytoxicity Properties. Journal of Medicinal Chemistry, 2007, 50, 3795-3803. PMID: 17622130

Deschamps, J. D.; Gautschi, J. T.; Whitman, S.; Johnson, T. A.; Gassner, N. C.; Crews, P.; Holman, T. H. Discovery of Platelet-type 12-Human Lipoxygenase Selective Inhibitors by High-throughput Screening of Structurally Diverse Libraries. Bioorganic & Medicinal Chemistry, 2007, 15, 6900-6908. PMID: 17826100.

Sonnenschein, R. N.; Johnson, T. A.; Tenney, K.; Valeriote, F.; Crews, P. A Reassignment of (-)-Mycothiazole and the Isolation of a Related Diol. Journal of Natural Products, 2006, 6, 145- 147. PMID: 16441088

Segraves, E. N.; Shah, R. R.; Segraves, N. L.; Johnson, T. A.; Whitman, S.; Sui, J. K.; Kenyon, V. A.; Cichewicz, R. H.; Crews, P.; Holman, T. Probing the Activity of Simple and Complex Brominated Aryl Compounds against 15-Soybean, 15-Human, and 12-Human Lipoxygenase. Journal of Medicinal Chemistry, 2004, 47, 4060-4065. PMID: 15267244

Amagata, T.; Whitman, S.; Johnson, T. A.; Stessman, C. C.; Loo, C. P.; Lobkovsky, E.; Clardy, J.; Crews, P.; Holman, T.; Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity against 12-Human, 15-Human, and 15-Soybean Lipoxygenases. Journal of Natural Products, 2003, 66, 230-235. PMID: 12608855

Seagraves, N. L.; Lopez, S.; Johnson, T. A.; Said, S. A.; Fu, X.; Schmitz, F. J.; Pietraszkiewicz, H.; Valeriote, F. A.; Crews, P. Structures and Cytotoxicities of Fascaplysin and Related Alkaloids from Two Marine Phyla__Fascaplysinopsis Sponges and Didemnum Tunicates. Tetrahedron Letters, 2003, 44, 3471-3475.

Thale, Z.; Johnson, T. A.; Tenney, K.; Wenzel, P. J.; Lobkvovsky, E.; Clardy, J.; Media, J.; Pietraszkiewicz, H.; Valeriote, F. A.; Crews, P. Structures and Cytotoxic Properties of Sponge-Derived Bisannulated Acridines. Journal of Organic Chemistry, 2002, 67, 9384-9391. PMID: 12492342