Full List - Dr. Duzgunes

Publications (1999 - present)

  • K. Konopka, B. Fallah, J. Monzon-Duller, N. Overlid, A. Lim and N. Düzgünes (2005) Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: Application to HSV-tk/ganciclovir-mediated cytotoxicity. Cell. Mol. Biol Lett. 10:455-470.
  • S. Simões, A. Filipe, H. Faneca, M. Mano, N. Penacho, N. Düzgünes and M.C. Pedroso de Lima (2005) Cationic liposomes for gene delivery. Expert Opin. Drug Deliv 2:237-254.
  • K. Konduri, S. Nandedkar, D. A. Rickaby, N. Düzgünes and P. R. J. Gangadharam (2005) The use of sterically stabilized liposomes to treat asthma. Methods Enzymol. 391:413-427.
  • N. Düzgünes, S. Simões, V. Slepushkin, E. Pretzer, D. Flasher, I. I. Salem, G. Steffan, K. Konopka and M. C. Pedroso de Lima (2005) Delivery of antiviral agents in liposomes. Methods Enzymol. 391:351-373.
  • I.I. Salem, D. L. Flasher and N. Düzgünes (2005) Liposome-encapsulated antibiotics. Methods Enzymol. 391:261-291.
  • N. Düzgünes and G. Gregoriadis (2005) The origins of liposomes: Alec Bangham at Babraham. Methods Enzymol. 391:1-3.
  • N. Düzgünes, ed. (2005) Liposomes, Part E. Methods in Enzymology, Vol. 391, xxxvii + 489 pp., Elsevier/Academic Press, San Diego.
  • S. Yan, Y. Xingju, Y. Takaoka, S-I .Oh-i, N. Düzgünes and S. Hirota (2004) Comparison of the shape parameters of DNA-cationic-lipid complexes and model polyelectrolyte-lipid complexes. J. Coll. Interface Sci. 276:317-322.
  • K. Konopka, A. Lee, N. Moser-Kim, S. Saghezchi, A. Kim, A. Lim, V. V. Suzara and N. Düzgünes (2004) Gene transfer to human oral cancer cells via non-viral vectors and HSV-tk/ganciclovir-mediated cytotoxicity: Potential for suicide gene therapy. Gene Ther. Mol. Biol. 8:307-318.
  • T. Alpagot, N. Düzgünes, L.F. Wolff and A. Lee (2004) Risk factors for periodontitis in HIV patients. J. Periodontal Res. 39:149-157.
  • V. Slepushkin, S. Simões, M. C. Pedroso de Lima and N. Düzgünes (2004) Sterically stabilized pH-sensitive liposomes. Methods Enzymol. 387:134-147.
  • N. Düzgünes, ed. (2004) Liposomes, Part D. Methods in Enzymology, Vol. 387, xxxiv + 343 pp., Elsevier/Academic Press, San Diego.
  • S. Simões, J.N. Moreira, C. Fonseca, N. Düzgünes and M. C. Pedroso de Lima (2004) On the formulation of pH-sensitive liposomes with long circulation times. Adv. Drug Deliv. Rev. 56:947-965.
  • R. Zhdanov, E. Bogdanenko, A. Moskovtsev, O. Podobed and N. Düzgünes (2003) Liposome-mediated gene delivery: Dependence on lipid structure, glycolipid-mediated targeting and immunological properties. Meth. Enzymol. 373:433 465.
  • S. Simões, P. Pires, M. T. Girão da Cruz, N. Düzgünes and M. C. Pedroso de Lima (2003) Gene delivery by cationic liposome-DNA complexes containing transferrin or serum albumin. Meth. Enzymol. 373:369-383.
  • C. Tros de Ilarduya, M. A. Arangoa and N. Düzgünes (2003) Transferrin lipoplexes with protamine-condensed DNA for serum-resistant gene delivery. Meth. Enzymol. 373:342-356.
  • M. C. Pedroso de Lima, H. Faneca, M. Mano, N. Penaacho, N. Düzgünes and S. Simões (2003) Biophysical characterization of cationic liposome-DNA complexes and their interaction with cells. Meth. Enzymol. 373:298-312.
  • N. Düzgünes, ed. (2003) Liposomes, Part C. Methods in Enzymology, Vol. 373, xxxviii + 596 pp., Elsevier/Academic Press, San Diego.
  • N. Düzgünes (2003) Fluorescence assays for liposome fusion. Methods. Enzymol. 372:260-274.
  • N. Düzgünes, ed. (2003) Liposomes, Part B. Methods in Enzymology, Vol. 372, xxxvi + 479 pp., Elsevier/Academic Press, San Diego.
  • N. Düzgünes (2003) Preparation and quantitation of small unilamellar liposomes and large unilamellar reverse-phase evaporation liposomes. Methods Enzymol. 367:23-27.
  • N. Düzgünes, ed. (2003) Liposomes, Part A. Methods in Enzymology, Vol. 367, xxxii + 311 pp., Elsevier/Academic Press, San Diego.
  • B. Dorocka-Bobkowska, K. Konopka and N. Düzgünes (2003) Influence of antifungal polyenes on the adhesion of Candida albicans and Candida glabrata to human epithelial cells in vitro. Arch. Oral Biol. 48(12):805-14.
  • Y. Sun, X. Li, N. Düzgünes, Y. Takaoka, S. Ohi and S. Hirota (2003) The shape parameter of liposomes and DNA-lipid complexes determined by viscometry utilizing small sample volumes. Biophys. J. 85, 1223-1232.
  • N. Düzgünes, L.A. Bagatolli, P. Meers, Y.-K. Oh and R.M. Straubinger. (2003) Fluorescence methods in liposome research. In: Liposomes: A Practical Approach, 2nd Ed. (V. Weissig and V. Torchilin, eds.), pp. 105-147, Oxford University Press, Oxford.
  • I.I. Salem, G. Steffan and N. Düzgünes (2003) Efficacy of clofazimine -modified cyclodextrin against Mycobacterium avium complex in human macrophages. Int. J. Pharm. 260:105-114.
  • M.C. Pedroso de Lima, S. Neves, A. Filipe, N. Düzgünes and S. Simões (2003) Cationic liposomes for gene delivery: From biophysics to biological applications. Curr. Med. Chem. 10:1221-1232.
  • N. Düzgünes, C. Tros de Ilarduya, S. Simões, R.I. Zhdanov, K. Konopka and M.C. Pedroso de Lima (2003) Cationic liposomes for gene delivery: Novel cationic lipids and enhancement by proteins and peptides. Curr. Med. Chem. 10:1213-1220.
  • K.S. Konduri, S. Nandedkar, N. Düzgünes, V. Suzara, J. Artwohl and R. Bunte (2003) Efficacy of liposomal budenoside in experimental asthma. J. Allergy Clin. Immunol. 111:321-327.
  • I.I. Salem and N. Düzgünes (2003) Efficacies of cyclodextrin-complexed and liposome-encapsulated clarithromycin against Mycobacterium avium complex infection in human macrophages. Int. J. Pharm. 250:403-414.
  • M.A. Arangoa, N. Düzgünes and C. Tros de Ilarduya (2003) Increased receptor-mediated gene delivery to the liver by protamine-enhanced asialofetuin-lipoplexes. Gene Therapy 10:5-14.
  • S. Simões, C. Fonseca, H. Faneca, N. Düzgünes and M.C. Pedroso de Lima (2002) Protein-associated lipoplexes: Novel strategies to enhance gene delivery mediated by lipid-based particles. STP Pharma Sciences 12:339-344.
  • N.R. Shine, K. Konopka, S.C. Wang, E.A. Burks, N. Düzgünes and C.P. Whitman (2002) Secretory leukocyte protease inhibitor: Inhibition of human immunodeficiency virus type 1 infection of monocytic THP-1 cells by a newly cloned protein. Bioorg. Chem. 30:249-263.
  • A.K. Ghosh, E. Pretzer, H. Cho, K.A. Hussain & N. Düzgünes (2002) Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease. Antiviral Res. 54:29-36.
  • C. Tros de Ilarduya, M.A. Arangoa, M.J. Moreno-Aliaga and N. Düzgünes (2002) Enhanced gene delivery in vitro and in vivo by improved transferrin-lipoplexes. Biochim. Biophys. Acta 1561:209-221.
  • I. Nunes-Correia, A. Eulálio, S. Nir, N. Düzgünes, J. Ramalho-Santos, and M.C. Pedroso de Lima (2002) Fluorescent probes for monitoring virus fusion kinetics: Comparative evaluation of reliability. Biochim. Biophys. Acta 1561:65-75.
  • K. Konopka and N. Düzgünes (2002) Expression of CD4 controls the susceptibility of THP-1 cells to infection by CCR5- and CXCR4-dependent HIV Type 1 isolates. AIDS Res. Hum. Retroviruses 18:123-131.
  • N. Düzgünes, S. Simões, P. Pires and M.C. Pedroso de Lima (2002) Gene delivery by cationic liposome-DNA complexes. In: Polymeric Biomaterials (S. Dumitriu, ed.), pp. 943-958, Marcel Dekker, New York.
  • N. Düzgünes, S. Simões, K. Konopka, J.J. Rossi and M.C. Pedroso de Lima (2001) Delivery of novel macromolecular drugs against HIV-1. Expert Opin. Biol. Ther. 1:949-970.
  • S. Simões, V. Slepushkin, N. Düzgünes and M.C. Pedroso de Lima (2001) On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes. Biochim. Biophys. Acta 1515:23-37.
  • N. Düzgünes, S. Simões, V. Slepushkin, E. Pretzer, J.J. Rossi, E. De Clercq, V.P. Antao, M.L. Collins and M.C. Pedroso de Lima (2001) Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic oligonucleotide phosphonate analogs delivered in pH-sensitive liposomes. Nucleosides Nucleotides Nucleic Acids 20:515-523.
  • N. Düzgünes (2001) Preface: Lipid assemblies for drug delivery. Adv. Drug Deliv. Rev. 47:137-138.
  • N. Düzgünes, ed. (2001) Lipid assemblies for drug delivery. Adv. Drug Deliv. Rev. 47:137-294.
  • M.C. Pedroso de Lima, S. Simões, P. Pires, H. Faneca and N. Düzgünes (2001) Cationic lipid-DNA complexes in gene delivery: From biophysics to biological applications. Adv. Drug Deliv. Rev. 47:277-294.
  • K. Konopka, N.S. Lee, J.J. Rossi and N. Düzgünes (2000) Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication. Gene 255:235-244.
  • S. Simões, V. Slepushkin, R. Gaspar, M.C. Pedroso de Lima and N. Düzgünes (2000) Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum. Biochim. Biophys. Acta 1463:459-469.
  • C. Tros de Ilarduya and N. Düzgünes (2000) Efficient gene transfer by transferrin lipoplexes in the presence of serum. Biochim. Biophys. Acta 1463:333-342.
  • S. Simões, V. Slepushkin, R. Gaspar, M.C. Pedroso de Lima and N. Düzgünes (1999) Successful transfection of lymphocytes by ternary lipoplexes. Bioscience Rep. 19:601-609.
  • K. Konopka, N. Shine, E. Pretzer and N. Düzgünes (1999) Secretory leukocyte protease inhibitor: Oxidation of SLPI does not explain its variable anti-HIV activity. J. Dental Res. 78:1773-1776.
  • S. Simões, V. Slepushkin, R. Gaspar, M.C. Pedroso de Lima and N. Düzgünes (1999) Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands of pH-sensitive peptides. Gene Ther. 6:1798-1807.
  • N. Düzgünes and S. Nir (1999) Mechanisms and kinetics of liposome-cell interactions. Adv. Drug Deliv. Rev. 40:3-18.
  • K. Konopka, L.S.S. Guo and N. Düzgünes (1999) Anti-HIV activity of amphotericin B-cholesteryl sulfate colloidal dispersion in vitro. Antiviral Res. 42:197-209.
  • P. Pires, S. Simões, S. Nir, R. Gaspar, N. Düzgünes and M.C. Pedroso de Lima (1999) Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells. Biochim. Biophys. Acta 1418:71-84.
  • S. Simões, P. Pires, N. Düzgünes and M.C. Pedroso de Lima (1999) Cationic liposomes as gene transfer vectors: Barriers to successful application in gene therapy. Curr. Opin. Mol. Therapeut. 1:147-157.
  • N. Düzgünes, E. Pretzer, S. Simões, V. Slepushkin, K. Konopka, D. Flasher and M. C. Pedroso de Lima (1999) Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells. Mol. Membr. Biol. 16:111-118.
  • M. Pedroso de Lima, S. Simões, P. Pires, R. Gaspar, V. Slepushkin and N. Düzgünes (1999) Gene delivery mediated by cationic liposomes: from biophysical aspects to enhancement of transfection. Mol. Membr. Biol. 16:103-109.
  • S. Simões, V. Slepushkin, E. Pretzer, P. Dazin, R. Gaspar, M.C. Pedroso Lima and N. Düzgünes (1999) Transfection of human macrophages by lipoplexes via the combined use of targeting ligands and pH-sensitive peptides. J. Leukocyte Biol. 65:270-279.

Patents

  • G. Steffan, I.I. Salem & N. Düzgünes. Water-soluble iminophenazine derivative-containing pharmaceutical complexes, their preparation and use. German Patent DE 198 14814 A1.
  • G. Steffan, H.-J. Galla, N. Düzgünes & C. Henke. Sterol-conjugated, anionic cyclodextrin derivative and its use in drug formulations. German Patent DE 198 14815 C2.
  • N. Düzgünes, S. Simões, V. Slepushkin & M. C. Pedroso de Lima. Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles. US Patent US 6,245,427 B1.